Memorial Sloan-Kettering Cancer Center Group Leader, Innovation Lab in New York, New York
Group Leader, Innovation Lab
Job Posting Number: 14544
Research – Other
June 26, 2017
At Memorial Sloan Kettering (MSK), we’re not only changing the way we treat cancer, but also the way the world thinks about it. By working together and pushing forward with innovation and discovery, we’re driving excellence and improving outcomes.
For the 27th year, MSK has been named a top hospital for cancer by U.S. News & World Report. We are proud to be on Becker’s Healthcare list as one of the 150 Great Places to Work in Healthcare in 2016, as well as Glassdoor’s annual Employees’ Choice Awards 2017. We’re treating cancer, one patient at a time. Join us and make a difference every day.
The mission of the Marie-Josée and Henry R. Kravis Center for Molecular Oncology (CMO) is to promote precision oncology through genomic analysis to guide the diagnosis and treatment of cancer patients. The CMO brings together clinicians and scientists throughout MSKCC to conduct large-scale translational research involving molecular characterization of patient tumor specimens in order to identify correlations between genomic features and clinical outcomes.
The Innovation Laboratory within the CMO is a group of experimental and computational scientists dedicated to the creation and optimization of genomic assays for near-term clinical use. The goals of the Innovation Laboratory are to develop and validate genomic assays and associated computational pipelines for the molecular characterization of human tumors, to evaluate emerging technologies for potential clinical utility, to pilot them with clinical and translational investigators, and to work with clinical laboratories to ensure quality standards mandated by CLIA. Once established, these assays can be deployed retrospectively to discover biomarkers that predict with therapeutic response or resistance, and prospectively to guide treatment decisions and direct patients to promising clinical trials. Active areas of research include isolating and sequencing of circulating cell-free DNA from plasma and other bodily fluids, optimization of DNA and RNA capture techniques, molecular profiling of challenging clinical samples (FFPE tissue, small biopsies, cytological specimens), and single-cell genomics applications.
A highly organized and self-directed scientist with hands-on experience performing genome-scale analysis of clinical material.
Committed to applying genomic techniques for clinical benefit.
Someone who thrives in a fast-paced, dynamic environment with changing priorities.
A person who enjoys working in a team, is self-motivated, can manage multiple tasks simultaneously, and can solve problems independently.
Experienced in both experimental and computational cancer genomic methodologies.
Someone with strong leadership qualities and committed to managing an integrated team of experimental and computational scientists.
An excellent communicator.
A methodical and detail-oriented scientist.
Direct and supervise the activities or experimental and computational laboratory staff in technology development activities and projects.
Prioritize overall technology development initiatives to meet departmental and center goals, and delegate work to lab members.
Design and perform experiments to develop and validate genomic assays.
Provide technical guidance and respond to questions raised by staff to ensure timely completion of experiments and analyses.
Draft technical procedures and written summaries, and present results in multiple venues.
Oversee computational analysis in collaboration with bioinformatics group members to evaluate the performance of new technologies and implement appropriate data analysis pipelines and workflows.
Manage collaborative pilot projects to apply new technologies to characterize molecular alterations in clinical tumor specimens.
Serve as the primary contact for principal investigators and research staff regarding technology development initiatives and pilot projects.
Work with leadership in the Center for Molecular Oncology and clinical departments to assess molecular technology needs and opportunities, and assess the clinical potential of emerging technologies.
Communicate with sales and technical representatives from technology vendors to learn about new products and services, and co-develop pilot experiments to evaluate their performance.
PhD in cancer biology, computational biology, or a related field.
At least 5 years of postgraduate training in academic or corporate research.
Hands-on experience with genome scale analysis of clinical material including nucleic acid isolation, instrumentation and automation, massively parallel DNA and RNA sequencing, experimental design, and bioinformatics analysis.
Strong organizational and troubleshooting abilities, attention to detail and accuracy, and outstanding communication skills.
Extensive management and administrative experience
Prior involvement in cancer genomics research using human tissue samples
Experience in computer programming#LI-SB1
MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.
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